ISW1

Symbol: ISW1
Name: Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
Entrez gene ID: 852547
Species: Yeast (Taxid: 4932)

Functional description:
Isw1p; Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation [Source:SGD;Acc:S000000449] [Ensembl]; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p called Isw1a and a complex with Ioc2p and Ioc4p called Isw1b; Isw1a and Isw1b have both partially overlapping and distinct roles with Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation [SGD]

Observation:

Replicative lifespan decreased by 35% in the alpha strain



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SMARCA5 (9606)
  • SMARCA5 (9598)
  • SMARCA5 (9615)
  • SMARCA5 (9913)
  • Smarca5 (10090)
  • Smarca5 (10116)
  • SMARCA5 (9031)
  • smarca5 (7955)
  • ISW1 (4932)
  • KLLA0F06710g (28985)
  • AGOS_AFL040W (33169)
  • GeneID:2674262 (148305)
  • NCU03875 (5141)
  • CHR11 (3702)
  • CHR17 (3702)
  • Os01g0367900 (4530)
  • Os05g0150300 (4530)



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