Denigma

IPT1

Symbol: IPT1
Name: InositolPhosphoTransferase 1
Entrez gene ID: 851644
Ensembl gene ID: YDR072C
Species: Yeast (Taxid: 4932)

Functional description:
Ipt1p; Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin [Source:SGD;Acc:S000002479] [Ensembl]

Observation:

Transposon-mediated mutation of IPT1 increases oxidative stress resistance and chronological lifespan by 40% [16527275]. IPT1 deletion decreases replicative lifespan by 30% in the alpha strain [19030232].



Interventions:
  • IPT1 transposition +40%
  • IPT1 deletion -30%

    • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • IPT1 (4932)
  • KLLA0E10187g (28985)

    • Note: Does the transposition lead to a gain- or loss-of-function?

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