IPK1

Symbol: IPK1
Name: Inositol Polyphosphate Kinase 1
Alias: GSL1
Entrez gene ID: 851910
Ensembl gene ID: YDR315C
Species: Yeast (Taxid: 4932)

Functional description:
Ipk1p; Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable [Source:SGD;Acc:S000002723] [Ensembl]

Observation:

Deletion of IPK1 increases mean replicative lifespan by 41 - 40% in the alpha strain [16293764; 19030232]. IPK1 deletion extends mean and maximum replicative lifespan by 24 and 19%, respectively, and was non-synergistic with moderate DR [21584246].



Interventions:
  • IPK1 deletion +24 to +40% +19%

  • Assays: Replicative Lifespan
    Mean: +24 to +41
    Maximum: +19

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IPK1 (4932)
  • KLLA0E12673g (28985)
  • AGOS_AAL037C (33169)



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