Symbol: IPK1 Name: Inositol Polyphosphate Kinase 1 Alias: GSL1 Entrez gene ID: 851910 Ensembl gene ID: YDR315C Species: Yeast (Taxid: 4932) Functional description: Ipk1p; Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable [Source:SGD;Acc:S000002723] [Ensembl] Observation: Deletion of IPK1 increases mean replicative lifespan by 41 - 40% in the alpha strain [16293764; 19030232]. IPK1 deletion extends mean and maximum replicative lifespan by 24 and 19%, respectively, and was non-synergistic with moderate DR [21584246]. Interventions: Assays: Replicative Lifespan Mean: +24 to +41 Maximum: +19 Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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