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Symbol: INP53 Name: Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains Entrez gene ID: 854276 Ensembl gene ID: YOR109W Species: Yeast (Taxid: 4932) Functional description: Inp53p; Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains [Source:SGD;Acc:S000005635] [Ensembl] Observation: Deletion of INP53 increases mean replicative lifespan by 31% [16293764]. INP53 deletion increases replicative lifespan by 31% in the alpha strain and by 10% in the a strain [18340043]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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