Denigma: Factor

INM1

Symbol: INM1
Name: INositol Monophosphatase 1
Entrez gene ID: 856442
Ensembl gene ID: YHR046C
Species: Yeast (Taxid: 4932)

Functional description:
Inm1p; Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate [Source:SGD;Acc:S000001088] [Ensembl]

Observation:

Deletion of INM1 increases replicative lifespan [16293764]. INM1 deletion results in an replicative lifespan increase by 50% in the alpha strain and a decrease by 10% in a strain [19030232].

Interventions:

INM1 deletion -10 to +50%

Assays: Replicative Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge