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Symbol: cco-1 Name: Cytochrome C Oxidase Entrez gene ID: 172832 Ensembl gene ID: F26E4.9 Species: Worm (Taxid: 6239) Functional description: Cytochrome C oxidase Vb (complex IV); Protein CCO-1; Cytochrome C Oxidase family member (cco-1) [Source:RefSeq peptide;Acc:NP_492601] [Ensembl]; cco-1 encodes the ortholog of the nuclear-encoded cytochrome c oxidase-1 subunit Vb/COX4, a component of the electron transport chain in mitochondria; knock-down of cco-1 via RNA interference in specific tissues like body wall muscle decreases life span, whereas knock-down in the nervous system and intestine increases life-span; the effects of cco-1 on life span indicate that the electron transport chain functions in a tissue-specific manner to affect the aging process, and studies show that this effect is dependent on the mitochondrial unfolded protein response. [WormBase] Observation: RNA interference of cco-1 results in a 45-61% increase in mean lifespan (in fer-15; fem-1 and N2 background, respectively) [16103914]. RNAi against cco-1 increases mean and maximum lifespan by 73% and 90%, respectively [12471266]. cco-1 RNAi extends mean and maximum lifespan by 41 and 50%. RNAi of cco-1 during the larval stages is necessary and sufficient for increased lifespan, while only during the adulthood it fails to to extend lifespan. cco-1 RNAi results in reduced pharyngeal pumping, defecation, motility, and body size as well as reduced ATP levels (by 60-80%) and oxygen consumption. daf-16 mutation fails to prevent lifespan extenison by RNAi of cco-1 and mutation of daf-2 further extends the lifespan of cco-1 RNAi animals [12447374]. RNAi of cco-1 only during the adulthood increases mean and 75th %ile lifespan by 22-32 and 16-33%, respectively [22560223]. Interventions: Assays: Organismal Lifespan Mean: +73 Maximum: +90 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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