Symbol: HST2
Name: Homolog of SIR Two (SIR2) 2
Entrez gene ID: 856092
Ensembl gene ID: YPL015C
Species: Yeast
(Taxid: 4932)
Functional description:
Hst2p; Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro [Source:SGD;Acc:S000005936] [Ensembl]
Observation:
HST2 overexpression extends replicative lifespan. 0.5% glucose restriction does not increase lifespan of sir2;fob1;hst2 triple mutants [16051752]. DR increases lifespan of all four sir2;fob1;hstX(X = sirtuin) triple mutants [16741098; 17129213].
Interventions:
HST2 overexpression
Assays:
Replicative Lifespan
Classification:
Aging-Suppressor
Positive Aging-Suppressor
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
SIRT2
(9606)
SIRT2
(9598)
SIRT2
(9615)
SIRT2
(9913)
Sirt2
(10090)
Sirt2
(10116)
sirt2
(7955)
Sirt2
(7227)
AgaP_AGAP002943
(7165)
hst2
(4896)
HST2
(4932)
KLLA0F11033g
(28985)
AGOS_AGL018C
(33169)
GeneID:5048967
(148305)
NCU00523
(5141)
Orthologs
Sirt3
(10090)
LOC100425019
(9544)
LOC723467
(9544)
SIRT3
(9544)
sir-2.3
(6239)
SIRT2
(9606)
Sirt5
(10116)
Sirt4
(10116)
SIRT5
(9544)
Sirt2
(7227)
Sirt2
(10116)
sir-2.2
(6239)
Sirt3
(10116)
SIRT5
(9606)
SIRT4
(9606)
SIRT3
(9606)
hst2
(4896)
Sirt4
(7227)
Sirt5
(10090)
Sirt4
(10090)
Sirt2
(10090)
Sirt3
(10090)
LOC100425019
(9544)
LOC723467
(9544)
SIRT3
(9544)
sir-2.3
(6239)
SIRT2
(9606)
Sirt5
(10116)
Sirt4
(10116)
SIRT5
(9544)
Sirt2
(7227)
Sirt2
(10116)
sir-2.2
(6239)
Sirt3
(10116)
SIRT5
(9606)
SIRT4
(9606)
SIRT3
(9606)
hst2
(4896)
Sirt4
(7227)
Sirt5
(10090)
Sirt4
(10090)
Sirt2
(10090)
Sirt3
(10090)
LOC100425019
(9544)
LOC723467
(9544)
SIRT3
(9544)
sir-2.3
(6239)
SIRT2
(9606)
Sirt5
(10116)
Sirt4
(10116)
SIRT5
(9544)
Sirt2
(7227)
Sirt2
(10116)
sir-2.2
(6239)
Sirt3
(10116)
SIRT5
(9606)
SIRT4
(9606)
SIRT3
(9606)
hst2
(4896)
Sirt4
(7227)
Sirt5
(10090)
Sirt4
(10090)
Sirt2
(10090)
Note: Overexpression results in replicative lifespan extension. ChronologicalLS extension or no life span prolongation during CR accordingly
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