GUT2

Symbol: GUT2
Name: Glycerol UTilization 2
Entrez gene ID: 854651
Ensembl gene ID: YIL155C
Species: Yeast (Taxid: 4932)

Functional description:
Gut2p; Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner [Source:SGD;Acc:S000001417] [Ensembl]

Observation:

Overexpression of GUT2 extends replicative lifespan by 25% and does not synergize with 0.5% glucose restriction [18381895].



Interventions:
  • GUT2 overexpression +25%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • Y50E8A.6 (6239)
  • gut2 (4896)
  • GUT2 (4932)
  • KLLA0A00418g (28985)
  • AGOS_AFR295W (33169)
  • PFC0275w (5833)

  • Orthologs
  • Y50E8A.6 (6239)
  • GPD2 (9544)
  • Gpd2 (10116)
  • CG2137 (7227)
  • Gpd2 (10090)
  • T25G3.4 (6239)
  • gut2 (4896)
  • GPD2 (9606)
  • CG7311 (7227)
  • Gpo-1 (7227)
  • Y50E8A.6 (6239)
  • GPD2 (9544)
  • Gpd2 (10116)
  • CG2137 (7227)
  • Gpd2 (10090)
  • T25G3.4 (6239)
  • gut2 (4896)
  • GPD2 (9606)
  • CG7311 (7227)
  • Gpo-1 (7227)



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