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Symbol: CAT Name: catalase Entrez gene ID: 847 Ensembl gene ID: ENSG00000121691 Species: Human (Taxid: 9606) Functional description: Catalase, converts hydrogen peroxide to water; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. [UniProt] Observation: Overexpression of human catalase targeted to mitochondria (MCAT) extends mean and maximum lifespan by about 20% in mice. Inactivation of aconitase in heat mitochondria and mitochondrial damage is also reduced in long-lived CAT mutant mice [15879174]. The MCAT strain has a reduced severity of age-dependent arteriosclerosis and increased genomic stability, as indicated by an decrease in oxidative stress and mitochondrial deletions in heart and muscle tissues. Median and maximum lifespan in increased about 17 - 21% [16144468].CAT was not found to be associated with longevity [15472150]. Interventions: Assays: Organismal Lifespan Mean: +20 Median: +17 to +21 Maximum: +17 to +21 Longevity Associated Variants: Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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