DOA4

Symbol: DOA4
Name: Degradation Of Alpha 4
Alias: DOS1;MUT4;NPI2;SSV7;UBP4
Entrez gene ID: 851641
Ensembl gene ID: YDR069C
Species: Yeast (Taxid: 4932)

Functional description:
Doa4p; Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole [Source:SGD;Acc:S000002476] [Ensembl]

Observation:

Deletion of DOA4 decreases replicative lifespan by 50% in the alpha strain [19030232].



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • DOA4 (4932)
  • KLLA0E10275g (28985)
  • AGOS_AFR007W (33169)



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