Casp2

Symbol: Casp2
Name: caspase 2
Entrez gene ID: 12366
Ensembl gene ID: ENSMUSG00000029863
Species: Mouse (Taxid: 10090)

Functional description:
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. May be important in multistep carcinogenesis. [UniProt]

Observation:

Loss of caspase-2 resulted in a shortened (10%) maximum lifespan and in enhanced aging-related traits such as impaired hair growth, increased bone loss, and reduced body fat content [17188333].



Interventions:
  • Casp-2 deficiency -10%

  • Assays: Organismal Lifespan
    Maximum: -10

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 17188333: Caspase-2 deficiency enhances aging-related traits in mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CASP2 (9606)
  • CASP2 (9598)
  • CASP2 (9615)
  • CASP2 (9913)
  • Casp2 (10090)
  • Casp2 (10116)
  • CASP2 (9031)
  • casp2 (7955)
  • ced-3 (6239)

  • Inparanoids
  • ENSMUSP00000031895 (10090)
  • ENSRNOP00000022672 (10116)
  • ENSMUSP00000031895 (10090)
  • ENSMUSP00000031895 (10090)



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