CYT1

Symbol: CYT1
Name: cytochrome c1
Alias: cytochrome;c1;CTC1;YOR29-16
Entrez gene ID: 854231
Species: Yeast (Taxid: 4932)

Functional description:
Cyt1p; Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex [Source:SGD;Acc:S000005591] [Ensembl]

Observation:

Deletion of CYT1 increases replicative lifespan by 15% in the alpha strain and decreases replicative lifespan by 20% in a strain. Deletion of CYT1 decreases replicative lifespan and cancels out replicative lifespan extension by HAP4 overexpression. Initially, it was shown that deletion of CYT1 also prevents lifespan extension by 0.5% glucose restriction [12124627], but later it was shown that either 0.5 or 0.05 % glucose restriction increases replicative lifespan of cyt1Delta cells [16311627].



Interventions:
  • CYT1 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Gero-Suppressant
  • DR-Essential Paralog
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CYC1 (9606)
  • CYC1 (9598)
  • LOC475121 (9615)
  • CYC1 (9913)
  • Cyc1 (10090)
  • Cyc1 (10116)
  • cyc1 (7955)
  • CG4769 (7227)
  • AgaP_AGAP006936 (7165)
  • cyc-1 (6239)
  • cyt1 (4896)
  • CYT1 (4932)
  • KLLA0F16555g (28985)
  • AGOS_ADR208W (33169)
  • GeneID:2676187 (148305)
  • NCU09816 (5141)
  • AT3G27240 (3702)
  • AT5G40810 (3702)
  • Os05g0301700 (4530)
  • Os01g0935700 (4530)
  • PF14_0597 (5833)

  • Orthologs
  • CYC1 (9606)
  • Cyc1 (10090)
  • Cyc1 (10116)
  • cyc-1 (6239)
  • cyt1 (4896)
  • CG14508 (7227)
  • CG4769 (7227)
  • CYC1 (9544)
  • CYC1 (9606)
  • Cyc1 (10090)
  • Cyc1 (10116)
  • cyc-1 (6239)
  • cyt1 (4896)
  • CG14508 (7227)
  • CG4769 (7227)
  • CYC1 (9544)
  • CYC1 (9606)
  • Cyc1 (10090)
  • Cyc1 (10116)
  • cyc-1 (6239)
  • cyt1 (4896)
  • CG14508 (7227)
  • CG4769 (7227)
  • CYC1 (9544)

  • Note: NA PG?

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