Symbol: CYT1 Name: cytochrome c1 Alias: cytochrome;c1;CTC1;YOR29-16 Entrez gene ID: 854231 Species: Yeast (Taxid: 4932) Functional description: Cyt1p; Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex [Source:SGD;Acc:S000005591] [Ensembl] Observation: Deletion of CYT1 increases replicative lifespan by 15% in the alpha strain and decreases replicative lifespan by 20% in a strain. Deletion of CYT1 decreases replicative lifespan and cancels out replicative lifespan extension by HAP4 overexpression. Initially, it was shown that deletion of CYT1 also prevents lifespan extension by 0.5% glucose restriction [12124627], but later it was shown that either 0.5 or 0.05 % glucose restriction increases replicative lifespan of cyt1Delta cells [16311627]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Note: NA PG? Edit \ Update (Admin) | Delete |
Comment on This Data Unit