Denigma

car

Symbol: car
Name: carnation
Entrez gene ID: 32947
Ensembl gene ID: FBgn0000257
Species: Fly (Taxid: 7227)

Functional description:
Vps 33, sec1 protein; Required for the biogenesis of eye pigment granules. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. [UniProt]

Observation:

Loss-of-function mutation in car results in reduction of mean lifespan by 34 - 63% and maximum lifespan by 28 - 29% [17435236].



Interventions:
  • car mutation -34 to -63% -28 to -29%

    • Assays: Organismal Lifespan
    Mean: -34 to -53
    Maximum: -28 to -29

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • VPS33A (9606)
  • VPS33A (9598)
  • VPS33A (9615)
  • VPS33A (9913)
  • Vps33a (10090)
  • Vps33a (10116)
  • VPS33A (9031)
  • vps33a (7955)
  • LOC100332420 (7955)
  • car (7227)
  • AgaP_AGAP003203 (7165)
  • vps33 (4896)
  • GeneID:2680884 (148305)
  • NCU09121 (5141)
  • ATVPS33 (3702)
  • Os04g0223000 (4530)
  • PFI1700c (5833)

    • Inparanoids
  • FBpp0074496 (7227)
  • ENSMUSP00000031388 (10090)
  • ENSRNOP00000011458 (10116)
  • ENSMMUP00000023702 (9544)
  • ENSP00000267199 (9606)
  • YLR396C (4932)
  • SPBC1703.15c (4896)



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