CTF4

Symbol: CTF4
Name: Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
Entrez gene ID: 856254
Ensembl gene ID: YPR135W
Species: Yeast (Taxid: 4932)

Functional description:
Ctf4p; Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion [Source:SGD;Acc:S000006339] [Ensembl]

Observation:

Deletion of CTF4 results in an approximately 75% reduced mean replicative lifespan [12024027].



Interventions:
  • CTF4 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • mcl1 (4896)
  • CTF4 (4932)
  • KLLA0B11099g (28985)
  • AGOS_AAR103C (33169)
  • GeneID:2685142 (148305)
  • NCU08484 (5141)



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