CAT5

Symbol: CAT5
Name: CATabolite repression 5
Entrez gene ID: 854292
Ensembl gene ID: YOR125C
Species: Yeast (Taxid: 4932)

Functional description:
Cat5p; Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation [Source:SGD;Acc:S000005651] [Ensembl]

Observation:

Deletion of CAT5 decreases chronological lifespan by up to 50% [17492370] and also decreases replicative lifespan by 30% in the alpha strain [18340043].



Interventions:
  • CAT5 deletion -30 to -50%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • COQ7 (9606)
  • COQ7 (9598)
  • COQ7 (9615)
  • COQ7 (9913)
  • Coq7 (10090)
  • Coq7 (10116)
  • COQ7 (9031)
  • zgc:158731 (7955)
  • COQ7 (7227)
  • clk-1 (6239)
  • coq7 (4896)
  • CAT5 (4932)
  • KLLA0E02421g (28985)
  • AGOS_ACL162C (33169)
  • GeneID:2674104 (148305)
  • NCU03957 (5141)

  • Orthologs
  • clk-1 (6239)
  • clk-1 (6239)



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