Denigma

BMH1

Symbol: BMH1
Name: Brain Modulosignalin Homologue 1
Alias: APR6
Entrez gene ID: 856924
Ensembl gene ID: YER177W
Species: Yeast (Taxid: 4932)

Functional description:
Bmh1p; 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling [Source:SGD;Acc:S000000979] [Ensembl]

Observation:

Deleting BMH1 extends chronological lifespan by 25% and is associated with activated stress response, decreased ROS levels and increased heat-shock-element-driven transcription activity. BMH1 deletion was non-additive with the genetic DR mimetic cdc25 and tor1. Water starvation (a form of extreme DR) extends chronological lifespan of BMH1 mutant even more as it does in wild-type. BMH1 genetically interacts with DR as well as TOR- and PKA-signaling pathways to regulate lifespan. Phosphorylation of Ser238 on Bmh1 increases during chronological aging, which is delayed by DR or reduced TOR activity [19805817].



Interventions:
  • BMH1 deletion +25%

    • Assays: Chronological Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • ywhae2 (7955)
  • rad25 (4896)
  • BMH1 (4932)
  • BMH2 (4932)
  • KLLA0F12100g (28985)
  • AGOS_AGR107C (33169)
  • GeneID:2679302 (148305)
  • NCU02806 (5141)
  • GF14_PHI (3702)
  • GRF2 (3702)
  • GRF1 (3702)
  • Os08g0480800 (4530)

    • Orthologs
  • Ywhab (10090)
  • Sfn (10090)
  • SFN (9606)
  • Ywhae (10090)
  • LOC709723 (9544)
  • YWHAQ (9606)
  • LOC298795 (10116)
  • rad25 (4896)
  • SFN (9544)
  • YWHAQ (9544)
  • LOC681140 (10116)
  • YWHAE (9544)
  • Ywhae (10116)
  • Ywhag (10116)
  • YWHAG (9544)
  • par-5 (6239)
  • 14-3-3epsilon (7227)
  • Ywhab (10116)
  • YWHAB (9544)
  • LOC707194 (9544)
  • M117.3 (6239)
  • Ywhag (10090)
  • 14-3-3zeta (7227)
  • ftt-2 (6239)
  • Ywhah (10090)
  • Ywhaq (10090)
  • Ywhaz (10090)
  • Ywhah (10116)
  • Ywhaq (10116)
  • Ywhaz (10116)
  • YWHAE (9606)
  • YWHAG (9606)
  • YWHAH (9606)
  • YWHAZ (9606)
  • YWHAH (9544)
  • YWHAB (9606)
  • Ywhab (10090)
  • Sfn (10090)
  • SFN (9606)
  • Ywhae (10090)
  • LOC709723 (9544)
  • YWHAQ (9606)
  • LOC298795 (10116)
  • rad25 (4896)
  • SFN (9544)
  • YWHAQ (9544)
  • LOC681140 (10116)
  • YWHAE (9544)
  • Ywhae (10116)
  • Ywhag (10116)
  • YWHAG (9544)
  • par-5 (6239)
  • 14-3-3epsilon (7227)
  • Ywhab (10116)
  • YWHAB (9544)
  • LOC707194 (9544)
  • M117.3 (6239)
  • Ywhag (10090)
  • 14-3-3zeta (7227)
  • BMH2 (4932)
  • ftt-2 (6239)
  • Ywhah (10090)
  • Ywhaq (10090)
  • Ywhaz (10090)
  • Ywhah (10116)
  • Ywhaq (10116)
  • Ywhaz (10116)
  • YWHAE (9606)
  • YWHAG (9606)
  • YWHAH (9606)
  • YWHAZ (9606)
  • YWHAH (9544)
  • YWHAB (9606)
  • BMH2 (4932)



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