ATP1

Symbol: ATP1
Name: ATP synthase 1
Entrez gene ID: 852177
Ensembl gene ID: YBL099W
Species: Yeast (Taxid: 4932)

Functional description:
Atp1p; Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000000195] [Ensembl]

Observation:

Deletion of ATP1 increases chronological lifespan by up to 50% [17492370], but decreases replicative lifespan by 70% in the alpha strain [18340043].



Interventions:
  • ATP1 deletion -70 to +50%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ATP5A1 (9606)
  • ATP5A1 (9615)
  • ATP5A1 (9913)
  • Atp5a1 (10090)
  • Atp5a1 (10116)
  • ATP5A1 (9031)
  • atp5a1 (7955)
  • blw (7227)
  • AgaP_AGAP005134 (7165)
  • H28O16.1 (6239)
  • atp1 (4896)
  • ATP1 (4932)
  • KLLA0E06667g (28985)
  • AGOS_AGL272C (33169)
  • GeneID:2683679 (148305)
  • NCU02514 (5141)
  • AT2G07698 (3702)
  • atp1 (3702)
  • atp1 (4530)
  • PFB0795w (5833)

  • Note: Different effects on replicative and chronological lifespan.

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