AKR1

Symbol: AKR1
Name: AnKyrin Repeat-containing protein 1
Entrez gene ID: 851857
Ensembl gene ID: YDR264C
Species: Yeast (Taxid: 4932)

Functional description:
Akr1p; Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats [Source:SGD;Acc:S000002672] [Ensembl]

Observation:

Deletion of AKR1 decreases replicative lifespan by 40% in the alpha strain [18340043]. Replicative lifespan decreased by 50% in the alpha strain [19030232].



Interventions:
  • AKR1 deletion -40 to -50%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ZDHHC17 (9606)
  • ZDHHC17 (9598)
  • ZDHHC17 (9615)
  • ZDHHC17 (9913)
  • Zdhhc17 (10090)
  • Zdhhc17 (10116)
  • ZDHHC17 (9031)
  • zdhhc17 (7955)
  • Hip14 (7227)
  • AgaP_AGAP011732 (7165)
  • SPAC2F7.10 (4896)
  • AKR1 (4932)
  • KLLA0E16721g (28985)
  • AGOS_AER388C (33169)
  • GeneID:2683302 (148305)
  • NCU08218 (5141)
  • TIP1 (3702)
  • Os06g0644500 (4530)
  • Os02g0184000 (4530)



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