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Symbol: cul-3 Entrez gene ID: 178547 Ensembl gene ID: Y108G3AL.1 Species: Worm (Taxid: 6239) Functional description: Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme (By similarity). Required to target mei- 3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule stability in the early embryo. [UniProt] Observation: RNAi decreased lifespan of daf-2, but did not affect significantly the lifespan of WT or glp-1 mutant. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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