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Symbol: trim-9 Name: TRIpartite Motif-containing protein homolog 9 Entrez gene ID: 178619 Ensembl gene ID: C39F7.2 Species: Worm (Taxid: 6239) Functional description: Predicted Zn-finger protein; Protein TRIM-9; Protein TRIM-9, isoform a [Source:UniProtKB/TrEMBL;Acc:Q9UAQ3] [Ensembl]; trim-9 encodes a protein containing RBCC/TRIM, fibronectin type III, and SPRY domains that is the sole C. elegans member of the C1 subfamily of tripartite motif (TRIM) proteins and is homologous to human MID1/TRIM18, mutations in which result in Opitz G/BBB syndrome, a congenital malformation disorder affecting ventral midline structures and resulting in mental retardation; in C. elegans, TRIM-9 functions cell autonomously as a specificity factor in an UNC-6/Netrin, and UNC-40/DCC-mediated pathway that regulates axon branch formation and attractive axon guidance in multiple neuronal types by potentiating UNC-40 activity; in addition, TRIM-9 is required for ventral recruitment of MIG-10/Lamellopodin in the HSNs during outgrowth; TRIM-9 also functions cell autonomously in body wall muscle in an UNC-40/DCC and UNC-73/Rho-GEF-mediated pathway to regulate muscle arm extension to ventral midline motor axons; TRIM-9 physically interacts with both UNC-40 and UNC-73 and may potentiate the in vivo interaction between UNC-40 and UNC-73; a TRIM-9::GFP fusion protein is expressed in neurons, hypodermis, and muscle cells; expression is also seen in the anchor cell, the ventral uterine precursor cells and in the ray precursors and descendants in males; in neurons, TRIM-9 colocalizes with UNC-40 to the ventral axon branches that require its function; in body wall muscle, TRIM-9 localizes to the dense bodies and colocalizes to the muscle arm termini with UNC-40 and UNC-73. [WormBase] Observation: RNA interference of trim-9 extends lifespan [15998808]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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