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Symbol: pas-1 Entrez gene ID: 179941 Ensembl gene ID: C15H11.7 Species: Worm (Taxid: 6239) Functional description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). [UniProt] Observation: RNAi against pas-1 started after the animal reached the late L4 stage decreases mean lifespan by 18-19% [22103665]. RNAi pas-1 decreases lifespan of daf-2 mutant, but not of WT or glp-1 mutant [17392428]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: Discrepance! Edit \ Update (Admin) | Delete |
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