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Symbol: yrs-1 Name: tYrosinyl tRNA Synthetase Entrez gene ID: 177237 Ensembl gene ID: K08F11.4 Species: Worm (Taxid: 6239) Functional description: Protein YARS-1; tYrosinyl tRNA Synthetase family member (yrs-1) [Source:RefSeq peptide;Acc:NP_741382] [Ensembl]; yrs-1 encodes a tyrosinyl tRNA synthetase predicted to be mitochondrial. This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. [WormBase] Observation: RNA interference increased mean lifespan by 55%. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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