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Symbol: C33H5.18 Entrez gene ID: 3565046 Ensembl gene ID: C33H5.18 Species: Worm (Taxid: 6239) Functional description: Protein C33H5.18; Probable phosphatidate cytidylyltransferase [Source:UniProtKB/Swiss-Prot;Acc:P53439] [Ensembl]; C33H5.18 encodes a CDP-diglyceride synthetase ortholog required for locomotion and osmoregulation; given its biochemical function in other organisms, C33H5.18 is expected to catalyse synthesis of cytidine diphosphate-diacylglycerol (CDP-DAG), an activated precursor for anionic and zwitterionic phospholipids, and is likely to regulate phosphatidylinositol lipid signalling; one might expect loss of C33H5.18 function to be lethal, but its deficiency may be supplemented by lipids in food. [WormBase] Observation: RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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