Denigma

vit-5

Symbol: vit-5
Name: VITellogenin structural genes (yolk protein genes) 5
Entrez gene ID: 180630
Ensembl gene ID: C04F6.1
Species: Worm (Taxid: 6239)

Functional description:
function in embryongensis and in the lipoprotein formation and oxidation pathways during germ line development; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Potential). [UniProt]

Observation:

RNA interference against vit-5 extends mean lifespan by 10-22%. vit-5 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. RNAi knockdown of vit-5 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224].



Interventions:
  • vit-5 RNAi +10 to +22%

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • vit-6 (6239)
  • vit-5 (6239)
  • vit-4 (6239)
  • vit-3 (6239)
  • vit-2 (6239)
  • vit-1 (6239)



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