unc-76

Symbol: unc-76
Name: UNCoordinated
Entrez gene ID: 180014
Ensembl gene ID: C01G10.11
Species: Worm (Taxid: 6239)

Functional description:
Protein UNC-76; UNCoordinated family member (unc-76) [Source:RefSeq peptide;Acc:NP_506712] [Ensembl]; unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies. [WormBase]

Observation:

unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].

unc-76 mutants are uncoordinated [4366476].



Interventions:
  • unc-76 mutation +50%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • FEZ2 (9606)
  • FEZ2 (9598)
  • FEZ2 (9615)
  • FEZ2 (9913)
  • Fez2 (10090)
  • Fez2 (10116)
  • FEZ2 (9031)
  • si:ch211-57i17.1 (7955)
  • Unc-76 (7227)
  • AgaP_AGAP003014 (7165)
  • unc-76 (6239)



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