unc-52

Symbol: unc-52
Name: UNCoordinated 52
Entrez gene ID: 175126
Ensembl gene ID: ZC101.2
Species: Worm (Taxid: 6239)

Functional description:
Probable role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in muscle. [UniProt]

Observation:

RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224].



Interventions:
  • unc-52 RNAi

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Differential
  • DR-Induced
  • DR-Essential
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HSPG2 (9606)
  • HSPG2 (9913)
  • Hspg2 (10090)
  • HSPG2 (9031)
  • unc-52 (6239)



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