Symbol: unc-26 Name: UNCoordinated Entrez gene ID: 178284 Ensembl gene ID: JC8.10 Species: Worm (Taxid: 6239) Functional description: Protein UNC-26; UNCoordinated family member (unc-26) [Source:RefSeq peptide;Acc:NP_001023266] [Ensembl]; unc-26 encodes synaptojanin, a polyphosphoinositide phosphatase orthologous to human synaptojanin 1 (OMIM:604297, 309000, which when mutated leads to Lowe oculocerebrorenal syndrome); UNC-26 is required for normal locomotion, pharyngeal pumping, and defecation, and specifically, appears to function in multiple steps of synaptic vesicle recycling; UNC-26 may also play a role in cytoskeletal organization. [WormBase] Observation: Mutations in unc-26 extend lifespan by 30-50%. Lifespan extension is proposed to be similar to DR [9789046]. unc-26 mutants are uncoordinated, slow and have defects in pharyngeal pumping [4366476; 8462849]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit