unc-26

Symbol: unc-26
Name: UNCoordinated
Entrez gene ID: 178284
Ensembl gene ID: JC8.10
Species: Worm (Taxid: 6239)

Functional description:
Protein UNC-26; UNCoordinated family member (unc-26) [Source:RefSeq peptide;Acc:NP_001023266] [Ensembl]; unc-26 encodes synaptojanin, a polyphosphoinositide phosphatase orthologous to human synaptojanin 1 (OMIM:604297, 309000, which when mutated leads to Lowe oculocerebrorenal syndrome); UNC-26 is required for normal locomotion, pharyngeal pumping, and defecation, and specifically, appears to function in multiple steps of synaptic vesicle recycling; UNC-26 may also play a role in cytoskeletal organization. [WormBase]

Observation:

Mutations in unc-26 extend lifespan by 30-50%. Lifespan extension is proposed to be similar to DR [9789046].

unc-26 mutants are uncoordinated, slow and have defects in pharyngeal pumping [4366476; 8462849].



Interventions:
  • unc-26 mutation +30 to +50%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SYNJ1 (9606)
  • SYNJ1 (9598)
  • SYNJ1 (9615)
  • SYNJ1 (9913)
  • Synj1 (10090)
  • Synj1 (10116)
  • SYNJ1 (9031)
  • synj1 (7955)
  • synj (7227)
  • AgaP_AGAP012175 (7165)
  • unc-26 (6239)
  • syj1 (4896)
  • INP53 (4932)
  • INP52 (4932)
  • KLLA0F23551g (28985)
  • AGOS_AFL228W (33169)
  • GeneID:2677771 (148305)
  • NCU03298 (5141)



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