age-1

Symbol: age-1
Name: AGEing alteration 1
Alias: AGEing alteration AGE-1, abnormal DAuer Formation DAF-23
Entrez gene ID: 174762
Ensembl gene ID: B0334.8
Species: Worm (Taxid: 6239)

Functional description:
Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway. [UniProt]

Observation:

Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740].

RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672].

age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. age-1 RNAi and mutation extend lifespan by 30% and 100%, respectively [8700226; 8608934].



Interventions:
  • age-1 RNAi +36 to +99% +48 to +117%
  • age-1 mutation +99% +117%

  • Assays: Organismal Lifespan
    Mean: +40 to +99
    Maximum: +65 to +117

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PIK3CA (9606)
  • PIK3CA (9598)
  • PIK3CA (9615)
  • PIK3CA (9913)
  • Pik3ca (10090)
  • PIK3CA (9031)
  • LOC100334726 (7955)
  • LOC561737 (7955)
  • age-1 (6239)

  • Orthologs
  • Pik3c2b (10090)
  • Pik3c2a (10090)
  • Pik3c2g (10090)
  • Pik3ca (10090)
  • Pik3c2a (10116)
  • Pi3K68D (7227)
  • PIK3C2A (9606)
  • PIK3C2B (9606)
  • PIK3C2G (9606)
  • PIK3CA (9606)
  • PIK3C2G (9544)
  • LOC697202 (9544)
  • Pik3c2b (10116)
  • Pik3c2g (10116)
  • VPS34 (4932)
  • Pik3c2b (10090)
  • Pik3c2a (10090)
  • Pik3c2g (10090)
  • Pik3ca (10090)
  • Pik3c2a (10116)
  • Pi3K68D (7227)
  • PIK3C2A (9606)
  • PIK3C2B (9606)
  • PIK3C2G (9606)
  • PIK3CA (9606)
  • PIK3C2G (9544)
  • LOC697202 (9544)
  • Pik3c2b (10116)
  • Pik3c2g (10116)
  • F39B1.1 (6239)
  • vps-34 (6239)
  • VPS34 (4932)
  • vps-34 (6239)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit