Denigma: Factor

UCP2

Symbol: UCP2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Entrez gene ID: 7351
Ensembl gene ID: Y40G12A.1
Species: Human (Taxid: 9606)

Functional description:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. [UniProt]

Observation:

Overexpression of human UCP2 in the fly nervous system extends lifespan by 10-30%. Ubiquitous overexpression is lethal [16054055].

Interventions:

UCP2 overexpression +10 to +30%

Assays: Organismal Lifespan
Mean: +10 to +30

Classification:

Aging-Suppressor

Positive Aging-Suppressor

Type:

Gene

Protein coding

References:

16054055: Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

Aging Relevance Analysis/Source:

GenAge