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Symbol: tub-1 Name: TUBby-related Entrez gene ID: 174312 Ensembl gene ID: F10B5.4 Species: Worm (Taxid: 6239) Functional description: Has a role in fat regulation independent of daf-16. Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Functions in life span control via the insulin/IGF-1 pathway. Thought to be involved in neuronal trafficking. [UniProt] Observation: Mutation of tub-1 (alleles nr2004 and nr2044) leads to 20-25% life-extension dependent on daf-16 [16054097]. tub-1 mutation promotes increased fat accumulation [16054097]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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