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Symbol: Tsc1 Name: CG6147-PA Tuberous sclerosis complex genes 1 Entrez gene ID: 42862 Ensembl gene ID: FBgn0026317 Species: Fly (Taxid: 7227) Functional description: CG6147 gene product from transcript CG6147-RA; Tsc1 [Source:FlyBase gene name;Acc:FBgn0026317] [Ensembl]; The gene Tsc1 is referred to in FlyBase by the symbol Dmel\Tsc1 (CG6147, FBgn0026317). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: kinase binding. There is experimental evidence for 15 unique biological process terms, many of which group under: biological regulation; regulation of cellular process; negative regulation of biological process; cellular process; cellular component organization or biogenesis; regulation of cell proliferation; response to nutrient levels; response to stress; determination of adult lifespan; primary metabolic process. 27 alleles are reported. The phenotypes of these alleles are annotated with: fat body; rhabdomere; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Hamartin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [FlyBase] Observation: Ubiquitously overexpression of UAS constructs (via the daughterless (da)-GAL-4 driver) containing dTSC1 extends mean lifespan at 29°C by 14% [15186745]. Interventions: Assays: Organismal Lifespan Mean: +14 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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