TPK2

Symbol: TPK2
Name: Takashi's Protein Kinase 2
Alias: PKA2; YKR1; PKA3
Entrez gene ID: 855898
Ensembl gene ID: YPL203W
Species: Yeast (Taxid: 4932)

Functional description:
Tpk2p; cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase [Source:SGD;Acc:S000006124] [Ensembl]

Observation:

Deletion of TPK2 in a tpk1 and tpk3 double mutant background decreases PKA activity and extends replicative lifespan by approximately 25% in SGY446 strain [11000115].



Interventions:
  • TPK2 deletion +25%

  • Assays: Replicative Lifespan

    Classification:
  • Aging Associated


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PRKACB (9606)
  • PRKACB (9598)
  • PRKACB (9615)
  • PRKACB (9913)
  • Prkacb (10090)
  • Prkacb (10116)
  • PRKACB (9031)
  • prkacbb (7955)
  • Pka-C1 (7227)
  • AgaP_AGAP001384 (7165)
  • pka1 (4896)
  • TPK2 (4932)
  • KLLA0D03190g (28985)
  • AGOS_AFL090W (33169)
  • GeneID:2684523 (148305)
  • NCU06240 (5141)

  • Orthologs
  • pka1 (4896)
  • pka1 (4896)

  • Note: TPK2 is only Positive Gerontogenein TPK1 and TPK3 double mutant background.

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