Tor

Symbol: Tor
Name: Target of rapamycin
Alias: CG5092
Entrez gene ID: 47396
Ensembl gene ID: FBgn0021796
Species: Fly (Taxid: 7227)

Functional description:
Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiation. Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation. Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism. In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology. Rag GTPases act as activators of TORC1 in response to amino acid signals. [UniProt]

Observation:

Expression of a dominant-negative form of Tor extends lifespan [15186745]. Ubiquitious overexpression of dTOR with the da-GAL4 driver of UAS-dTOR(FRB) which contains the 11kDA FKB12-rapamycin binding domain led to a mean and maximum lifespan increase of 15% (24%) and 29% at 29°C and of 50% (26%) and 13% at 25°C, respectively [15186745].

Overexpression of the dominant-negative form of Tor specifically in the fat and muscle tissues is sufficient to extend the mean and maximum lifespan by 24 and 19%, respectively [15186745].

Overexpression of UAS-dTOR(WT) or UAS-dTOR(TED) prevents eclosion to adulthood [15186745].



Interventions:
  • Dominant negative Tor +15 to +50% +13 to +29%

  • Assays: Organismal Lifespan
    Mean: +15 to +50
    Maximum: +13 to +29

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 15186745: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MTOR (9606)
  • MTOR (9615)
  • MTOR (9913)
  • Mtor (10090)
  • Mtor (10116)
  • FRAP1 (9031)
  • mtor (7955)
  • Tor (7227)
  • AgaP_AGAP007873 (7165)
  • tor1 (4896)
  • TOR2 (4932)
  • KLLA0B13948g (28985)
  • AGOS_AFR420W (33169)
  • TOR (3702)
  • Os05g0235300 (4530)

  • Orthologs
  • TOR2 (4932)
  • MTOR (9606)
  • Mtor (10090)
  • Mtor (10116)
  • tor1 (4896)
  • TOR2 (4932)
  • Smg1 (7227)
  • MTOR (9606)
  • Mtor (10090)
  • Mtor (10116)
  • tor1 (4896)

  • Inparanoids
  • FBpp0080003 (7227)
  • ENSMUSP00000099510 (10090)
  • ENSRNOP00000014167 (10116)
  • ENSMMUP00000025391 (9544)
  • ENSP00000354558 (9606)
  • YJR066W (4932)
  • SPBC216.07c (4896)



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