top-1

Symbol: top-1
Name: TOPoisomerase
Entrez gene ID: 266847
Ensembl gene ID: M01E5.5
Species: Worm (Taxid: 6239)

Functional description:
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). [UniProt]

Observation:

RNA interference decreased median lifespan by 19% in wild type animals and 42% in daf-2 mutants.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • TOP1 (9606)
  • TOP1 (9598)
  • TOP1 (9615)
  • TOP1 (9913)
  • Top1 (10090)
  • Top1 (10116)
  • TOP1 (9031)
  • top1l (7955)
  • Top1 (7227)
  • AgaP_AGAP004078 (7165)
  • top-1 (6239)
  • top1 (4896)
  • TOP1 (4932)
  • KLLA0C06116g (28985)
  • AGOS_ACL008C (33169)
  • GeneID:2680887 (148305)
  • NCU09118 (5141)
  • TOP1ALPHA (3702)
  • TOP1BETA (3702)
  • Os08g0154600 (4530)



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