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Symbol: tag-60 Name: Temporarily Assigned Gene name Entrez gene ID: 177736 Ensembl gene ID: C01F6.6 Species: Worm (Taxid: 6239) Functional description: Protein MPZ-2; Temporarily Assigned Gene name family member (tag-60) [Source:RefSeq peptide;Acc:NP_741478] [Ensembl]; tag-60 encodes, by alternative splicing, five isoforms of an ortholog of Drosophila SIP1 that maintains epithelial integrity via regulation of Moesin activity, and of the human SLC9A3R1 (OMIM:604990), SLC9A3R2 (OMIM:606553), PDZK1 (OMIM:603831), and PDZD3(OMIM:607146) proteins that regulate plasma membrane exchanger activity; in C. elegans, tag-60 is required for normally short lifespan and for normal acetylcholine neurotransmission; large-scale expression studies report that tag-60 is expressed in larval and adult pharynx, intestine, excretory cell, and tail cells. [WormBase] Observation: RNA interference extends lifespan. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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