Name: Superoxide dismutase
Alias: CG11793; cSod; cSOD; Cu; Cu-Zn SOD; Cu/Zn sod; Cu/Zn SOD; Cu/Zn superoxide dismutase; Cu/ZnSOD; CuSOD; CuZn SOD; CuZn-SOD; CuZn-SOD1; CuZnSOD; Cu[2+]/Zn[2+]SOD; Dmel\CG11793; dSOD1; G; l(3)108; l(3)68Af'; l(3)G; Mn SOD; sod; SOD; Sod-1; SOD-1; sod1; Sod1; SOD1; To; To-1
Entrez gene ID: 39251
Ensembl gene ID: YJR104C
Species: Fly (Taxid: 7227)
cytosolic Cu,Zn superoxide dismutase that reduces superoxide anion to hydrogen peroxide; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt]
Simultaneous overexpression of catalase and Sod (alias Sod1) results in a one-third lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance, but neither has any effect on lifespan alone . General overexpression of Sod (also known as Cu/ZnSOD) alone is sufficient to extend lifespan by up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD has no added benefit, presumably due to a pre-existing excess of catalase . Sod1 reduction by knockdown or knockout blunts the lifespan extension by a high sugar-low protein diet, but not a low-calorie diet .
Sod mutant flies display infertility and a reduction in lifespan .
Assays: Organismal Lifespan
Aging Relevance Analysis/Source:
Note: Are Sod mutant and Sod knockout the same intervention?
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