Symbol: Sod1 Name: Superoxide dismutase Alias: CG11793; cSod; cSOD; Cu; Cu-Zn SOD; Cu/Zn sod; Cu/Zn SOD; Cu/Zn superoxide dismutase; Cu/ZnSOD; CuSOD; CuZn SOD; CuZn-SOD; CuZn-SOD1; CuZnSOD; Cu[2+]/Zn[2+]SOD; Dmel\CG11793; dSOD1; G; l(3)108; l(3)68Af'; l(3)G; Mn SOD; sod; SOD; Sod-1; SOD-1; sod1; Sod1; SOD1; To; To-1 Entrez gene ID: 39251 Ensembl gene ID: YJR104C Species: Fly (Taxid: 7227) Functional description: cytosolic Cu,Zn superoxide dismutase that reduces superoxide anion to hydrogen peroxide; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt] Observation: Simultaneous overexpression of catalase and Sod (alias Sod1) results in a one-third lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance, but neither has any effect on lifespan alone [8108730]. General overexpression of Sod (also known as Cu/ZnSOD) alone is sufficient to extend lifespan by up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD has no added benefit, presumably due to a pre-existing excess of catalase [9858546]. Sod1 reduction by knockdown or knockout blunts the lifespan extension by a high sugar-low protein diet, but not a low-calorie diet [22672579]. Sod mutant flies display infertility and a reduction in lifespan [2539600]. Interventions: Assays: Organismal Lifespan Mean: +48 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Note: Are Sod mutant and Sod knockout the same intervention? Edit \ Update (Admin) | Delete |
Comment on This Data Unit