Sod1

Symbol: Sod1
Name: Superoxide dismutase
Alias: CG11793; cSod; cSOD; Cu; Cu-Zn SOD; Cu/Zn sod; Cu/Zn SOD; Cu/Zn superoxide dismutase; Cu/ZnSOD; CuSOD; CuZn SOD; CuZn-SOD; CuZn-SOD1; CuZnSOD; Cu[2+]/Zn[2+]SOD; Dmel\CG11793; dSOD1; G; l(3)108; l(3)68Af'; l(3)G; Mn SOD; sod; SOD; Sod-1; SOD-1; sod1; Sod1; SOD1; To; To-1
Entrez gene ID: 39251
Ensembl gene ID: YJR104C
Species: Fly (Taxid: 7227)

Functional description:
cytosolic Cu,Zn superoxide dismutase that reduces superoxide anion to hydrogen peroxide; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt]

Observation:

Simultaneous overexpression of catalase and Sod (alias Sod1) results in a one-third lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance, but neither has any effect on lifespan alone [8108730]. General overexpression of Sod (also known as Cu/ZnSOD) alone is sufficient to extend lifespan by up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD has no added benefit, presumably due to a pre-existing excess of catalase [9858546]. Sod1 reduction by knockdown or knockout blunts the lifespan extension by a high sugar-low protein diet, but not a low-calorie diet [22672579].

Sod mutant flies display infertility and a reduction in lifespan [2539600].



Interventions:
  • Overexpression of Cat and Sod1 +30%
  • Sod overexpression +38%
  • Sod1 knockdown
  • Sod knockout
  • Sod mutation

  • Assays: Organismal Lifespan
    Mean: +48

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 8108730: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.
  • 9858546: FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies.
  • 22672579: Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster.
  • 2539600: Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SOD1 (9606)
  • SOD1 (9598)
  • SOD1 (9615)
  • SOD1 (9913)
  • SOD1 (9913)
  • Sod1 (10090)
  • Gm8566 (10090)
  • Sod1 (10116)
  • SOD1 (9031)
  • sod1 (7955)
  • Sod (7227)
  • SOD3 (7165)
  • sod-5 (6239)
  • sod-1 (6239)
  • sod1 (4896)
  • SOD1 (4932)
  • KLLA0E05567g (28985)
  • AGOS_AGL321W (33169)
  • GeneID:2682824 (148305)
  • NCU02133 (5141)
  • CSD1 (3702)
  • Os03g0351500 (4530)
  • Os07g0665200 (4530)

  • Inparanoids
  • FBpp0075958 (7227)
  • ENSMUSP00000023707 (10090)
  • ENSRNOP00000058241 (10116)
  • ENSMMUP00000002283 (9544)
  • ENSP00000270142 (9606)
  • YJR104C (4932)
  • SPAC821.10c (4896)

  • Note: Are Sod mutant and Sod knockout the same intervention?

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