SNF1

Symbol: SNF1
Name: Sucrose NonFermenting 1
Alias: CAT1; CCR1; GLC2; HAF3; PAS14
Entrez gene ID: 852088
Ensembl gene ID: YDR477W
Species: Yeast (Taxid: 4932)

Functional description:
Snf1p; AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis [Source:SGD;Acc:S000002885] [Ensembl]

Observation:

Forced overexpression (high-copy 2 micro expression) of SNF1 shortens replicative lifespan to 75% of wild-type and is accompanied by signs of premature ageing, including progressive sterility, enlargement and fragmentation of the nucleus, redistribution of Sir3 to the nucleus, and more rapid accumulation of extrachromosomal rDNA circles [10921902]. SNF1 overexpression also reduced chronological lifespan [19164565]. Deletion of SNF1 increases replicative lifespan by 50% in the alpha strain [19030232], but decreases chronological lifespan [21076178].



Interventions:
  • SNF1 deletion +50%
  • SNF1 overexpression -25%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Negative Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PRKAA2 (9606)
  • PRKAA2 (9598)
  • PRKAA2 (9615)
  • PRKAA2 (9913)
  • Prkaa2 (10090)
  • Prkaa2 (10116)
  • PRKAA2 (9031)
  • prkaa2 (7955)
  • SNF1A (7227)
  • AgaP_AGAP002686 (7165)
  • aak-2 (6239)
  • ssp2 (4896)
  • SNF1 (4932)
  • KLLA0A03806g (28985)
  • AGOS_AEL230W (33169)
  • GeneID:2675217 (148305)
  • NCU04566 (5141)
  • Os03g0289100 (4530)
  • Os08g0484600 (4530)

  • Orthologs
  • aak-2 (6239)
  • aak-2 (6239)



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