Symbol: smk-1 Name: SMEK (Dictyostelium Suppressor of MEK null) homolog 1 Entrez gene ID: 179243 Ensembl gene ID: F41E6.4 Species: Worm (Taxid: 6239) Functional description: Protein SMK-1; SMEK (Dictyostelium Suppressor of MEK null) homolog family member (smk-1) [Source:RefSeq peptide;Acc:NP_001023909] [Ensembl]; smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development. [WormBase] Observation: RNA interference of smk-1 completely suppresses the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. smk-1 RNAi decreases mean and maximum lifespan of similar level than daf-16 knockdown [16530049]. smk-1 RNAi only slightly shortens the lifespan of wild-type worms, but abolishes the extended lifespan of eat-2 mutants [17476212]. Loss of smk-1 by temperature sensitive allele suppresses the extended lifespan under optimal bDR, but not the response to DR itself [17476212]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Note: It only slightly shortens the lifespan of wild-type worms? Edit \ Update (Admin) | Delete |
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