skr-1

Symbol: skr-1
Name: SKp1 Related (ubiquitin ligase complex component)
Entrez gene ID: 172775
Ensembl gene ID: F46A9.5
Species: Worm (Taxid: 6239)

Functional description:
Protein SKR-1; SKp1 Related (ubiquitin ligase complex component) family member (skr-1) [Source:RefSeq peptide;Acc:NP_492513] [Ensembl]; The skr-1 gene encodes a homolog of Skp1 in S. cerevisiae that is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis. [WormBase]

Observation:

RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SKP1 (9606)
  • SKP1 (9598)
  • SKP1 (9615)
  • SKP1 (9913)
  • Skp1a (10090)
  • Skp1 (10116)
  • SKP1 (9031)
  • skp1 (7955)
  • skpB (7227)
  • skr-1 (6239)
  • skr-2 (6239)
  • skp1 (4896)
  • SKP1 (4932)
  • KLLA0E16941g (28985)
  • AGOS_ADR295C (33169)
  • GeneID:2675549 (148305)
  • NCU08991 (5141)
  • Os09g0539500 (4530)



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