SIP2

Symbol: SIP2
Name: SNF1-Interacting Protein 2
Entrez gene ID: 852664
Ensembl gene ID: YGL208W
Species: Yeast (Taxid: 4932)

Functional description:
Sip2p; One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane [Source:SGD;Acc:S000003176] [Ensembl]

Observation:

Deletion of the N-myristoylprotein SIP2 results in reduced resistance to nutrient deprivation and a 60% shorter lifespan accompanied by signs of accelerated aging such as loss of silencing from telomeres and mating loci, redistribution of Sir3 to the nucleolus, progressive sterility, nucleolar fragmentation and enlargement, and accumulation of extrachromosomal rDNA [10921902].

SIP2 deletion increases replicative lifespan by 20% in the alpha strain [19030232].

SIP1 null mutation causes increase in the intracellular ATP and NAD+ levels in both young cells (generation 0-1) and older cells (generation 4), but the increase is greater in older cells [10921902].



Interventions:
  • SIP2 deletion -60 to +20%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PRKAB2 (9606)
  • PRKAB2 (9598)
  • PRKAB2 (9615)
  • PRKAB2 (9913)
  • Prkab2 (10090)
  • Prkab2 (10116)
  • PRKAB2 (9031)
  • zgc:172285 (7955)
  • aakb-2 (6239)
  • aakb-1 (6239)
  • SPCC1919.03c (4896)
  • SIP2 (4932)
  • GeneID:2685103 (148305)
  • NCU03837 (5141)
  • AT5G21170 (3702)
  • Os05g0491200 (4530)

  • Note: Increase of lifespan in alpha strains contradicts previous studies. is SIP1 or SIP2 meant in the description?

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