sdhC

Symbol: sdhC
Name: succinate dehydrogenase, cytochrome b556 subunit
Entrez gene ID: 41340
Ensembl gene ID: FBgn0037873
Species: Fly (Taxid: 7227)

Functional description:
Succinate dehydrogenase C; Succinate dehydrogenase C [Source:FlyBase gene name;Acc:FBgn0037873] [Ensembl]; The gene Succinate dehydrogenase C is referred to in FlyBase by the symbol Dmel\SdhC (CG6666, FBgn0037873). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: succinate dehydrogenase activity; succinate dehydrogenase (ubiquinone) activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to oxidative stress; mitochondrial electron transport, succinate to ubiquinone. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Succinate dehydrogenase, cytochrome b subunit, conserved site; Succinate dehydrogenase, cytochrome b556 subunit; Succinate dehydrogenase, cytochrome b560 subunit; Succinate dehydrogenase/Fumarate reductase, transmembrane subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [FlyBase]

Observation:

Mutants expressing a dominant negative form of sdhC in the nervous system have a 22% reduced mean lifespan and signs of oxidative stress induction [17854771].



Assays: Organismal Lifespan

Classification:
  • Gerontogene
  • Negative Gerontogene


  • Type:
  • Gene
  • Protein coding

    References:
  • 17854771: A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SDHC (9606)
  • SDHC (9598)
  • SDHC (9615)
  • SDHC (9913)
  • SDHC (9913)
  • Sdhc (10090)
  • Sdhc (10116)
  • sdhc (7955)
  • SdhC (7227)
  • AgaP_AGAP010672 (7165)

  • Inparanoids
  • FBpp0081848 (7227)
  • ENSMUSP00000106968 (10090)
  • ENSRNOP00000004228 (10116)
  • ENSMMUP00000038516 (9544)
  • ENSP00000356953 (9606)
  • YKL141W (4932)
  • SPCC330.12c (4896)



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