Symbol: sdhC Name: succinate dehydrogenase, cytochrome b556 subunit Entrez gene ID: 41340 Ensembl gene ID: FBgn0037873 Species: Fly (Taxid: 7227) Functional description: Succinate dehydrogenase C; Succinate dehydrogenase C [Source:FlyBase gene name;Acc:FBgn0037873] [Ensembl]; The gene Succinate dehydrogenase C is referred to in FlyBase by the symbol Dmel\SdhC (CG6666, FBgn0037873). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: succinate dehydrogenase activity; succinate dehydrogenase (ubiquinone) activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to oxidative stress; mitochondrial electron transport, succinate to ubiquinone. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Succinate dehydrogenase, cytochrome b subunit, conserved site; Succinate dehydrogenase, cytochrome b556 subunit; Succinate dehydrogenase, cytochrome b560 subunit; Succinate dehydrogenase/Fumarate reductase, transmembrane subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [FlyBase] Observation: Mutants expressing a dominant negative form of sdhC in the nervous system have a 22% reduced mean lifespan and signs of oxidative stress induction [17854771]. Assays: Organismal Lifespan Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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