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Symbol: sbt-1 Name: Seven B Two (mammalian 7BT prohormone convertase chaperone) homolog Entrez gene ID: 180366 Ensembl gene ID: T03D8.3 Species: Worm (Taxid: 6239) Functional description: Protein SBT-1; Seven B Two (mammalian 7BT prohormone convertase chaperone) homolog family member (sbt-1) [Source:RefSeq peptide;Acc:NP_508020] [Ensembl]; sbt-1 encodes the C. elegans ortholog of the neuroendocrine chaperone 7B2; by homology, SBT-1 is predicted to function in the maturation/activation of the EGL-3/PC2 proprotein convertase; accordingly, mass spectrometry analysis indicates that sbt-1 activity is required for production of some neuropeptides; sbt-1 mutant animals are also aldicarb resistant, suggesting that SBT-1 is required for normal cholinergic signaling; in both in vitro and in vivo assays, SBT-1 facilitates maturation of vertebrate proPC2; sbt-1 promoter fusions are expressed in most neurons and in the pharynx; when expressed in DA cholinergic neurons under the control of the unc-129 promoter, SBT-1::YFP localizes to puncta adjacent to the synaptic vesicle reporter SNB-1::RFP. [WormBase] Observation: Mutation reduced maximum lifespan 15%. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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