Denigma

ry

Symbol: ry
Name: rosy
Entrez gene ID: 41605
Ensembl gene ID: FBgn0003308
Species: Fly (Taxid: 7227)

Functional description:
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). [UniProt]

Observation:

Loss-of-function mutation of ry reduces mean lifespan by 45% and maximum lifespan by 35% [17435236].



Interventions:
  • ry mutation -45% -35%

    • Assays: Organismal Lifespan
    Mean: -45
    Maximum: -35

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • XDH (9606)
  • XDH (9598)
  • XDH (9615)
  • XDH (9913)
  • Xdh (10090)
  • Xdh (10116)
  • XDH (9031)
  • xdh (7955)
  • ry (7227)
  • AgaP_AGAP007918 (7165)
  • F55B11.1 (6239)
  • GeneID:5050113 (148305)
  • NCU03350 (5141)
  • XDH1 (3702)
  • XDH2 (3702)
  • Os03g0429800 (4530)

    • Inparanoids
  • FBpp0082172 (7227)
  • ENSMUSP00000024866 (10090)
  • ENSRNOP00000009634 (10116)
  • ENSMMUP00000036635 (9544)
  • ENSP00000368727 (9606)



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