Denigma: Factor

ubh-4

Symbol: ubh-4
Name: UBiquitin C-terminal Hydrolase (family 1)
Entrez gene ID: 174289
Ensembl gene ID: C08B11.7
Species: Worm (Taxid: 6239)

Functional description:
Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). [UniProt]

Observation:

RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808].

Interventions:

ubh-4 RNAi +3% +8%

Assays: Organismal Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge