Denigma: Factor

rsks-1

Symbol: rsks-1
Name: RSK-pSeventy (RSK-p70 kinase) homolog
Entrez gene ID: 176554
Ensembl gene ID: Y47D3A.16
Species: Worm (Taxid: 6239)

Functional description:
Protein RSKS-1; RSK-pSeventy (RSK-p70 kinase) homolog family member (rsks-1) [Source:RefSeq peptide;Acc:NP_499447] [Ensembl]

Observation:

RNA interference reducing S6K (rsks-1) mRNA levels by about two-fold extends mean lifespan 13-47% and maximum lifespan by up to 60%. Deletion mutants also live longer. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extends lifespan of rsks-1 mutants [17266679]. DAF-16 reduces expression of rsks-1 [15253933;22560223]. Autophagy is reduced by knockdown of S6 kinase RSKS-1 [22560223], as it increases translation downstream of TORC1 but also promotes autophagy [15296714].

Interventions:

rsks-1 mutation

rsks-1 RNAi +13 to +47% +60%

Assays: Organismal Lifespan

Classification:

Gerontogene

Positive Gerontogene

References:

22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

15253933: The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

17266679: Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.

15296714: Role and regulation of starvation-induced autophagy in the Drosophila fat body.

Aging Relevance Analysis/Source: