Denigma

RPS18A

Symbol: RPS18A
Name: Ribosomal Protein of the Small subunit 18A
Alias: S18A
Entrez gene ID: 852061
Ensembl gene ID: YDR450W
Species: Yeast (Taxid: 4932)

Functional description:
Rps18ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins [Source:SGD;Acc:S000002858] [Ensembl]

Observation:

Deletion of both RPS18A and RPS18B paralogs increases replicative lifespan by moderately, but significantly by 15% [17174052]. Deletion of RPS18A alone does not effect mean replicative lifespan significantly [22377630].



Assays:
Median: +15

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • RPS18 (9606)
  • RPS18 (9615)
  • RPS18 (9913)
  • Rps18 (10090)
  • Rps18 (10116)
  • rps18 (7955)
  • RpS18 (7227)
  • AgaP_AGAP010375 (7165)
  • rps-18 (6239)
  • rps1801 (4896)
  • RPS18A (4932)
  • RPS18B (4932)
  • KLLA0B01562g (28985)
  • AGOS_AER315C (33169)
  • GeneID:2676017 (148305)
  • NCU00475 (5141)
  • AT1G34030 (3702)
  • PFL (3702)
  • RPS18C (3702)
  • Os03g0794700 (4530)
  • Os07g0173500 (4530)
  • Os07g0173700 (4530)
  • PF11_0272 (5833)

    • Note: RPS18A is only Positive Gerontogenein RPS18B mutant background. Assuming mean RLS. Deletion of RPS18A alone does not effect mean replicative lifespan significantly.

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