Denigma

RPL31A

Symbol: RPL31A
Name: Ribosomal Protein of the Large subunit 31A
Alias: RPL34; L31A; L34A; YL28
Entrez gene ID: 851484
Ensembl gene ID: YDL075W
Species: Yeast (Taxid: 4932)

Functional description:
Rpl31ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality [Source:SGD;Acc:S000002233] [Ensembl]

Observation:

Deletion of RPL31A increases mean replicative lifespan by 45% [16293764]. Mean replicative lifespan increases by 35% in the alpha strain and 50% in a strain [19030232; 18423200]. Mean replicative lifespan of the RPL31A deletion mutant increases by 35% in the ORF collection and by 29% in the remade strain [22377630]. RPL31A deletion increases significantly replicative lifespan [17174052]. Deletion of RPL31A extends replicative lifespan and is not further extended by 0.05% glucose restriction [18423200].



Interventions:
  • RPL31A deletion +29 to +50%

    • Assays: Replicative Lifespan
    Mean: +29-50

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • LOC459973 (9598)
  • LOC607833 (9615)
  • Gm10072 (10090)
  • LOC681338 (10116)
  • zgc:136896 (7955)
  • RpL31 (7227)
  • AgaP_AGAP011896 (7165)
  • rpl31 (4896)
  • RPL31B (4932)
  • RPL31A (4932)
  • KLLA0B02937g (28985)
  • AGOS_AER076C (33169)
  • GeneID:2676703 (148305)
  • NCU08344 (5141)
  • AT2G19740 (3702)
  • AT4G26230 (3702)
  • AT5G56710 (3702)
  • Os06g0319700 (4530)
  • Os02g0717800 (4530)
  • PFE0185c (5833)

    • Orthologs
  • RGD1561195 (10116)
  • LOC714120 (9544)
  • RPL31 (9606)
  • LOC680499 (10116)
  • RpL31 (7227)
  • LOC715088 (9544)
  • Gm8759 (10090)
  • LOC706340 (9544)
  • Rpl31 (10116)
  • LOC100359986 (10116)
  • rpl-31 (6239)
  • LOC719029 (9544)
  • Gm10072 (10090)
  • LOC714171 (9544)
  • LOC716358 (9544)
  • LOC694561 (9544)
  • LOC695373 (9544)
  • LOC695247 (9544)
  • LOC690384 (10116)
  • Rpl31 (10090)
  • LOC100504277 (10090)
  • LOC710744 (9544)
  • LOC693466 (9544)
  • LOC696027 (9544)
  • RGD1562547 (10116)
  • LOC711041 (9544)
  • LOC697214 (9544)
  • RGD1563551 (10116)
  • LOC100360252 (10116)
  • rpl31 (4896)
  • RGD1561841 (10116)
  • LOC708085 (9544)
  • LOC100361974 (10116)
  • RGD1564839 (10116)
  • LOC681338 (10116)
  • Gm6635 (10090)
  • LOC694937 (9544)
  • RGD1561195 (10116)
  • LOC714120 (9544)
  • RPL31 (9606)
  • LOC680499 (10116)
  • RpL31 (7227)
  • LOC715088 (9544)
  • Gm8759 (10090)
  • LOC706340 (9544)
  • Rpl31 (10116)
  • LOC100359986 (10116)
  • RPL31B (4932)
  • rpl-31 (6239)
  • LOC719029 (9544)
  • Gm10072 (10090)
  • LOC714171 (9544)
  • LOC716358 (9544)
  • LOC694561 (9544)
  • LOC695373 (9544)
  • LOC695247 (9544)
  • LOC690384 (10116)
  • Rpl31 (10090)
  • LOC100504277 (10090)
  • LOC710744 (9544)
  • LOC693466 (9544)
  • LOC696027 (9544)
  • RGD1562547 (10116)
  • LOC711041 (9544)
  • LOC697214 (9544)
  • RGD1563551 (10116)
  • LOC100360252 (10116)
  • rpl31 (4896)
  • RGD1561841 (10116)
  • LOC708085 (9544)
  • LOC100361974 (10116)
  • RGD1564839 (10116)
  • LOC681338 (10116)
  • Gm6635 (10090)
  • LOC694937 (9544)



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