RPL10

Symbol: RPL10
Name: Ribosomal Protein of the Large subunit 10
Entrez gene ID: 850764
Ensembl gene ID: YLR075W
Species: Yeast (Taxid: 4932)

Functional description:
Rpl10p; Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family [Source:SGD;Acc:S000004065] [Ensembl]

Observation:

Heterozygosity for RPL10 deletion increases median replicative lifespan by 24% [17174052].



Interventions:
  • RPL10 deletion +24%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RPL10L (9606)
  • RPL10L (9598)
  • RPL10L (9615)
  • Rpl10l (10090)
  • Rpl10l (10116)
  • rpl1002 (4896)
  • rpl1001 (4896)
  • RPL10 (4932)
  • KLLA0D05643g (28985)
  • AGOS_ABR235W (33169)
  • GeneID:2676714 (148305)
  • NCU08964 (5141)
  • Os03g0332500 (4530)

  • Note: Heterozygosity for rpl10D but not for rpl25D, bothLSU single copy RP genes, increased median replicative LS by 24%.

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