Denigma

RPD3

Symbol: RPD3
Name: Reduced Potassium Dependency 3
Alias: MOF6; REC3; SDI2; SDS6
Entrez gene ID: 855386
Ensembl gene ID: YNL330C
Species: Yeast (Taxid: 4932)

Functional description:
Rpd3p; Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members [Source:SGD;Acc:S000005274] [Ensembl]

Observation:

Deletion of the histone deacetylase gene RPD3 extends lifespan by 41%, independently of an intact Sir silencing complex (in the short lived YSK661 strain) [10512855]. Deletion of RPD3 extends replicative lifespan and there was no additive effect by neither 0.1% glucose nor amino acid restriction [12213553].

RPD3 deletion increases rDNA silencing in a partially SIR2-dependent manner [10082585]. Its effects on chromatin functional state were evidenced by enhanced silencing at the three known heterochromatic regions in the genome, the silent mating type (HM), subtelomeric, and rDNA loci, which occurred even in the absence of SIR3 [10512855].



Interventions:
  • RPD3 deletion +41%

    • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HDAC1 (9606)
  • LOC464259 (9598)
  • LOC487309 (9615)
  • HDAC1 (9913)
  • Hdac1 (10090)
  • Hdac1 (10116)
  • HDAC1 (9031)
  • hdac1 (7955)
  • Rpd3 (7227)
  • AgaP_AGAP006511 (7165)
  • hda-1 (6239)
  • clr6 (4896)
  • RPD3 (4932)
  • KLLA0E01981g (28985)
  • AGOS_AGR395W (33169)
  • GeneID:2684118 (148305)
  • NCU00824 (5141)
  • HDA9 (3702)

    • Orthologs
  • HDAC3 (9606)
  • hda-3 (6239)
  • LOC699642 (9544)
  • Hdac3 (7227)
  • Hdac1 (10116)
  • Gm10093 (10090)
  • Hdac8 (10090)
  • LOC703154 (9544)
  • LOC703416 (9544)
  • Hdac1 (10090)
  • HDAC8 (9606)
  • hda-2 (6239)
  • Hdac2 (10090)
  • Hdac3 (10090)
  • clr6 (4896)
  • Hdac8 (10116)
  • Rpd3 (7227)
  • Hdac1l (10116)
  • Hdac2 (10116)
  • Hdac3 (10116)
  • LOC704467 (9544)
  • LOC708441 (9544)
  • hda-1 (6239)
  • HDAC1 (9606)
  • HDAC2 (9606)
  • Rpd3 (7227)
  • HDAC3 (9606)
  • hda-3 (6239)
  • LOC699642 (9544)
  • Hdac3 (7227)
  • Hdac1 (10116)
  • Gm10093 (10090)
  • Hdac8 (10090)
  • LOC703154 (9544)
  • LOC703416 (9544)
  • Hdac1 (10090)
  • HDAC8 (9606)
  • hda-2 (6239)
  • Hdac2 (10090)
  • Hdac3 (10090)
  • clr6 (4896)
  • Hdac8 (10116)
  • Rpd3 (7227)
  • Hdac1l (10116)
  • Hdac2 (10116)
  • Hdac3 (10116)
  • LOC704467 (9544)
  • LOC708441 (9544)
  • hda-1 (6239)
  • HDAC1 (9606)
  • HDAC2 (9606)
  • Rpd3 (7227)
  • HDAC3 (9606)
  • hda-3 (6239)
  • LOC699642 (9544)
  • Hdac3 (7227)
  • Hdac1 (10116)
  • Gm10093 (10090)
  • Hdac8 (10090)
  • LOC703154 (9544)
  • LOC703416 (9544)
  • Hdac1 (10090)
  • HDAC8 (9606)
  • hda-2 (6239)
  • Hdac2 (10090)
  • Hdac3 (10090)
  • clr6 (4896)
  • Hdac8 (10116)
  • Rpd3 (7227)
  • Hdac1l (10116)
  • Hdac2 (10116)
  • Hdac3 (10116)
  • LOC704467 (9544)
  • LOC708441 (9544)
  • hda-1 (6239)
  • HDAC1 (9606)
  • HDAC2 (9606)



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