ROM2

Symbol: ROM2
Name: RhO1 Multicopy suppressor 2
Entrez gene ID: 851086
Ensembl gene ID: YLR371W
Species: Yeast (Taxid: 4932)

Functional description:
Rom2p; GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF [Source:SGD;Acc:S000004363] [Ensembl]

Observation:

Deletion of ROM2 increases mean replicative lifespan of the alpha strain by about 50% [16293764]. ROM deletion mutant replicative lifespan increases by 49% in the alpha strain and 16% in a strain. Deletion of ROM2 increases replicative lifespan by 38% in the alpha strain and by 29.3% in the a strain (34.2% in both) [19030232].



Interventions:
  • ROM2 deletion +16 to +50%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • rgf1 (4896)
  • ROM2 (4932)
  • KLLA0B07799g (28985)
  • AGOS_AFR585W (33169)
  • GeneID:2682617 (148305)
  • NCU00668 (5141)



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